| Property | Address | City | Date Listed |
|---|---|---|---|
| Albright House | 716--718 Ave. F | Fort Madison | 07/24/1978 |
| Atchison Topeka and Santa Fe Passenger and Freight Complex Historic District | 902 Ave. H | Fort Madison | 03/05/1992 |
| Beck Chief Justice Joseph M. House | 630 Avenue E | Fort Madison | 07/21/1988 |
| Belknap Gen. William Worth House | 511 N. 3rd Street | Keokuk | 10/10/1975 |
| Bridgeport Bridge | Old Quarry Rd. | Denmark vicinity | 5/15/98 |
| Cattermole Memorial Library | 614 7th Street | Fort Madison | 04/05/1984 |
| Curtis Gen. Samuel R. House | 206 High Street | Keokuk | 4/23/98 |
| Denmark Congregational Church | Academy Ave. and 4th Street | Denmark | 12/02/1977 |
| Faeth Farmstead and Orchard District | 2469 IA 2 | Fort Madison vicinity | 09/16/2005 |
| Fort Madison Bridge, (Highway Bridges of Iowa MPS) | IA 9 over Mississippi River | Fort Madison | 8/27/99 |
| Fort Madison Downtown Commercial Historic District | Centered on Ave. G, from near 6th St., to mid-900 Blk, inc. Ave. H, from 7th to 9th Sts. | Fort Madison | 08/31/07 |
| Geo M. Verity Keokuk River Museum | Victory Park | Keokuk | 12/20/1989 |
| Harrison E. H. House | 220 N. 4th Street | Keokuk | 01/12/1984 |
| Herschler Christian and Katharina House Barn and Outbuildings Historic District | Jct. of 6th and Green Sts. | Franklin | 02/16/1996 |
| Hotel Iowa | 401 Main Street | Keokuk | 02/05/1987 |
| Iowa State Penitentiary Cellhouses Historic District | Jct. of Avenue G and US 61 | Fort Madison | 12/18/1992 |
| Joy C. R. House | 816 Grand Ave. | Keokuk | 01/16/1997 |
| Keokuk Lock and Dam | At Mississippi River | Keokuk | 10/19/1978 |
| Keokuk National Cemetery | 1701 J Street | Keokuk | 06/04/1997 |
| Keokuk Union Depot | 200 Exchange St. | Keokuk - Owner ObjectionDetermined Eligible | 1/7/2002 |
| Keokuk Young Women's Christian Association Building | 425 Blondeau Street | Keokuk | 10/12/2004 |
| Lee, Captain Daniel S. and Fannie L. (Brooks), House | 803 1st St. E. | Independence | 01/07/2010 |
| Lee County Courthouse | 701 Ave. F | Fort Madison | 09/30/1976 |
| McConn, Daniel, Barn | 2095 IA 61 | Fort Madison vicinity | 5/26/2000 |
| McGreer, John, Barn and Crib | 2056 150th Avenue | Donnellson vicinity | 8/8/2001 |
| Miller Justice Samuel Freeman House | 318 N. 5th Street | Keokuk | 10/10/1972 |
| Moyce--Steffens House | 1615 Avenue H Fort | Madison | 05/02/1997 |
| Old Fort Madison Site | Address Restricted | Fort Madison | 05/07/1973 |
| The Park Place--Grand Avenue Residential District | 4th at Park Place and Orleans St. and N up Grand Ave. to Rand Park | Keokuk | 9/12/2002 |
| Primrose Mill | Off IA 2 | Primrose | 03/17/1983 |
| Saint Barnabas Episcopal Church | Chestnut Street | Montrose | 04/11/1986 |
| Sample Hugh W. and Sarah House | 205 N. Second Street | Keokuk | 11/22/1995 |
| Schlapp George E. House | 639 Ave. C | Fort Madison | 02/04/1982 |
| Sharon Cemetery Historic District | Co. Rd. J40 about 3 mi. E of Van Buren Co. line | Farmington | 01/11/1991 |
| Sheaffer Craig and Virginia House | 10 High Point | Fort Madison | 04/22/1993 |
| Sheaffer, Walter A. | 11 High Point | Fort Madison | 09/19/06 |
| St Mary of the Assumption Church | 1031 Ave. E | Fort Madison | 02/08/1980 |
| St. John's Episcopal Church and Parish Hall | 4th and Concert | Keokuk | 07/11/1989 |
| St. Peter Church | 301 S. 9th Street | Keokuk | 07/14/1983 |
| U.S. Post Office and Courthouse | 25 N. 7th Street | Keokuk | 01/24/1974 |
| Weber, Alois and Annie, House | 802 Orleans Avenue | Keokuk | 04/09/2002 |
| Weess Frank J. House | 224--226 Morgan Street | Keokuk | 05/22/1978 |